Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype
M. Maus, V. Lopez-Polo, M. Lafarga, M. Aguilera, E. De Lama, K. Meyer, A. Manonelles, A. Sola, C. Lopez Martinez, I. Lopez-Alonso, F. Hernandez-Gonzales, S. Chaib, M. Rovira, M. Sanchez, R. Faner, , M. Serrano
The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.
bioRxiv · Jul 29, 2022Physiology