K. Meyer

The WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation.

This study shows the WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation through in vivo biochemical approaches.

Plasma cell differentiation, antibody quality, and initial germinal center B cell population depend on glucose influx rate

This study shows that glucose influx is critical for germinal center function and plasma cell production, but plasma cells can also use alternative hexose sugars for antibody secretion.

Phosphorylation-controlled cohesion of a nuclear condensate regulates mRNA retention

The paper shows that phosphorylation controls nuclear speckle cohesion, affecting mRNA retention and that environmental stress alters this process.

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

Decoding of YAP levels and dynamics by pluripotency factors

The paper investigates how YAP activation levels and dynamics regulate pluripotency factors Oct4 and Nanog through differential thresholds and adaptive transcriptional responses.

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

Modified E2 glycoprotein of hepatitis C virus enhances pro-inflammatory cytokines and protective immune response in mice

This study modifies the HCV E2 glycoprotein to reduce CD81 binding, enhancing pro-inflammatory cytokines and protective immune response in mice.

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

Cross-tissue immune cell analysis reveals tissue-specific adaptations and clonal architecture across the human body

The paper analyzes immune cell diversity across 15 human tissues using single-cell RNA sequencing and VDJ sequencing, revealing tissue-specific features and clonal architecture of T and B cells.

SARS-CoV-2 spike protein expressing epithelial cells promotes senescence associated secretory phenotype in endothelial cells and increased inflammatory response

This study shows that SARS-CoV-2 spike protein-expressing epithelial cells induce senescence-associated secretory phenotype in endothelial cells, increasing inflammation and leukocyte adhesion.

CRISPR-Targeted CAR Gene Insertion Using Cas9/RNP and AAV6 Enhances Anti-AML Activity of Primary NK Cells

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Highly efficient site-directed gene insertion in primary human natural killer cells using homologous recombination and CRISPaint delivered by AAV

This paper develops a method for efficient site-directed gene insertion in primary human NK cells using CRISPaint and AAV delivery, achieving up to 89% mCherry expression.

Liquid-crystal organization of liver tissue

The paper reveals that hepatocytes in liver tissue follow a long-range liquid-crystal order, challenging the traditional view of random organization and highlighting bi-directional communication between hepatocytes and sinusoids.

A probabilistic model to identify the core microbial community

This paper introduces a probabilistic model to identify core microbial communities, revealing higher richness and diversity compared to conventional methods.

Mutations In Disordered Regions Cause Disease By Creating Endocytosis Motifs

The paper identifies mutations in disordered regions that create dileucine motifs, leading to clathrin-dependent trafficking and disease.