M. Aguilera

The Horizontal Ladder Test (HLT) protocol: A novel, optimized, and reliable means of assessing motor coordination in Sus scrofa domesticus

The paper introduces a novel horizontal ladder test (HLT) protocol for assessing motor coordination in pigs and validates its construct validity using voluntary alcohol consumption.

The efficacy of chemotherapy is limited by intratumoural senescent cells that persist through the upregulation of PD-L2

This study identifies PD-L2 as a marker of therapy-induced senescent cells that suppress chemotherapy efficacy, showing PD-L2 blockade enhances tumour remission in mice.

Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

The paper shows iron accumulation drives fibrosis, senescence, and SASP in mice and humans, and demonstrates MRI can detect fibrotic burden.

Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming

This study shows that a single cycle of transient OSKM expression reverses aging-related DNA methylation, transcriptional, and metabolic changes in multiple tissues of aged mice.

A plausible mechanism for Drosophila larva intermittent behavior.

This paper identifies intermittent behavior in Drosophila larvae and proposes a neural mechanism using a stochastic network model.