A. Suchenko

Structure and physiological investigation of arginylated actin

This study investigates the structure and function of arginylated beta-actin, showing structural similarity to non-arginylated actin but altered interactions with myosin-II and effects on cellular processes.

Structural Mechanisms of Actin Isoforms

The paper reports high-resolution structures of actin isoforms with native PTMs, revealing isoform-specific conformations and their functional implications.

Calponin-Homology Domain mediated bending of membrane associated actin filaments

This paper shows that the 'curly' domain from IQGAP proteins stabilizes curved actin filaments when anchored to lipid membranes, forming high-curvature rings and enabling contraction with myosin II.

N-terminal modification of actin by acetylation and arginylation determines the architecture and assembly rate of linear and branched actin networks

This study shows that acetylation and arginylation of actin's N-terminus differentially regulate actin polymerization dynamics and remodeling by actin-binding proteins, affecting network architecture and assembly rates.

Pick-ya actin: A method to purify actin isoforms with bespoke key post-translational modifications

Pick-ya actin is a method to produce actin isoforms with organism-specific post-translational modifications using synthetic biology in yeast.