T. Hatano

Connection between drug-mediated neurotransmission and salivary microbiome

This study investigates how CNS drugs affect the salivary microbiome and links these changes to cognitive function and neurodegeneration.

Structural Mechanisms of Actin Isoforms

The paper reports high-resolution structures of actin isoforms with native PTMs, revealing isoform-specific conformations and their functional implications.

mNeonGreen-tagged fusion proteins and nanobodies reveal localization of tropomyosin to patches, cables, and contractile actomyosin rings in live yeast cells

The paper develops mNeonGreen-tagged tropomyosin and nanobodies to visualize tropomyosin localization in yeast, revealing new structures and dynamics in actin cytoskeleton.

Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

N-terminal modification of actin by acetylation and arginylation determines the architecture and assembly rate of linear and branched actin networks

This study shows that acetylation and arginylation of actin's N-terminus differentially regulate actin polymerization dynamics and remodeling by actin-binding proteins, affecting network architecture and assembly rates.

Pick-ya actin: A method to purify actin isoforms with bespoke key post-translational modifications

Pick-ya actin is a method to produce actin isoforms with organism-specific post-translational modifications using synthetic biology in yeast.