Author

Y. Narui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:structural biology· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

M. Sotomayor· 4 shared D. Choudhary· 3 shared P. De-la-Torre· 3 shared R. Araya-Secchi· 2 shared A. A. Indzhykulian· 1 shared A. S. Arora· 1 shared A. Suchenko· 1 shared B. L. Neel· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

M. Sotomayor

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Elasticity and Thermal Stability are Key Determinants of Hearing Rescue by Mini-Protocadherin-15 Proteins

P. De-la-Torre, H. Wen, J. Brower, K. Martinez-Perez, Y. Narui, F. Yeh, E. Hale, M. V. Ivanchenko, D. P. Corey, M. Sotomayor, A. A. Indzhykulian

The paper identifies elasticity and thermal stability as critical factors determining the effectiveness of mini-protocadherin-15 proteins in rescuing hearing in USH1F mouse models.

bioRxiv · Jun 16, 2024 · PreprintBioengineering

Structural Mechanisms of Actin Isoforms

A. S. Arora, H.-L. Huang, R. Singh, Y. Narui, T. Hatano, S. Heissler, M. K. Balasubramanian, K. Chinthalapudi, A. Suchenko

The paper reports high-resolution structures of actin isoforms with native PTMs, revealing isoform-specific conformations and their functional implications.

bioRxiv · Aug 1, 2022Biochemistry

Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation

C. R. Nisler, Y. Narui, D. Choudhary, J. D. Bowman, V. J. Lynch, M. Sotomayor

This study investigates the evolutionary changes in the cadherin-23 and protocadherin-15 protein complex, showing how sequence variations affect biophysical properties and contribute to deafness-causing mutations across vertebrates.

bioRxiv · Jan 23, 2022Evolutionary Biology

Structural determinants of protocadherin-15 elasticity and function in inner-ear mechanotransduction

D. Choudhary, Y. Narui, B. L. Neel, L. N. Wimalasena, C. F. Klanseck, P. De-la-Torre, C. Chen, R. Araya-Secchi, E. Tamilselvan, M. Sotomayor

This study reports the structure of PCDH15 and its interactions with CDH23, revealing how its ectodomain functions as a gating spring in inner-ear mechanotransduction.

bioRxiv · Jul 8, 2019 · PreprintBiophysics

A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

P. De-la-Torre, D. Choudhary, R. Araya-Secchi, Y. Narui, M. Sotomayor

This study reports the crystal structure of PCDH15's MAD12 domain, showing it induces parallel dimerization and is mechanically weak, with implications for related cadherins.

bioRxiv · Nov 2, 2018Biophysics