M. E. Winkler

This paper identifies a novel pathway for mnm5s2U synthesis in Gram-positive bacteria, revealing alternative biosynthetic mechanisms involving the MnmL enzyme.

This paper identifies five CiaR-controlled Ccn sRNAs in S. pneumoniae that modulate Zn resistance and virulence by regulating metal homeostasis and detoxification mechanisms.

The paper identifies genetic modifications in Streptococcus pneumoniae that bypass the need for protein phosphorylation by altering MurZ and MurA activity.

This study investigates the role of RodZ and PBP1b in the PG elongasome of ovoid-shaped Streptococcus pneumoniae, showing RodZ as a scaffolding protein and PBP1b's involvement in elongasome regulation.

This study investigates the roles of RNase Y and PNPase in Streptococcus pneumoniae virulence and transcriptome regulation, showing their distinct impacts on gene expression and pathogenesis.

This paper investigates the spatial organization of peptidoglycan synthesis in Streptococcus pneumoniae during cell division, revealing distinct rings and nodes of transpeptidase activity and PBP localization.

This paper identifies CvfD, an S1-domain RNA-binding protein in Streptococcus pneumoniae, showing it regulates cold sensitivity, phosphate transport, and virulence through post-transcriptional mechanisms.

This study shows FtsZ treadmilling drives directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism, controlling enzyme processivity and sPG synthesis.

This study presents the structure of FtsX's extracellular loop and shows its essential interaction with PcsB for cell viability in Streptococcus pneumoniae.

This paper investigates FtsZ dynamics and its relationship to septal PG synthesis in Streptococcus pneumoniae, finding that FtsZ movement is continuous and independent of PG synthesis rate.