J. Meng

Additive and partially dominant effects from genomic variation contribute to rice heterosis

This study identifies heterosis-associated genes and metabolites in rice, showing additive and partially dominant genetic effects contribute to 17 agronomic traits and yield heterosis across species.

Influences of single mutation and retinal binding on the THz absorption spectra of CRABP-II based rhodopsin mimics

This study uses THz-TDS to analyze how retinal binding and single mutations affect the low-frequency absorption spectra of rhodopsin mimics.

Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae during bloodstream infection

The paper identifies that splenic red pulp macrophages, aided by natural antibodies and complement, clear liver-resistant Streptococcus pneumoniae from the bloodstream in mice.

Is M1-L121E a good mimic on microbial rhodopsin? A viewpoint from excited-state dynamics

This paper investigates the excited-state dynamics of a microbial rhodopsin mimic, M1-L121E, and finds it captures key features but shows distinct differences in photoreaction dynamics compared to natural rhodopsin.

Boosting Ascomycin Production through n-Butanol Addition in the Fermentation Process of Streptomyces hygroscopicus var. ascomyceticus ATCC 14891

This study enhances FK520 production in Streptomyces hygroscopicus by adding n-butanol, increasing yield by 1.72-fold and boosting precursor accumulation.

Engineered human myogenic cells in hydrogels generate functional myofibers within dystrophic mouse muscle

This study shows engineered human myogenic cells in hydrogels form functional myofibers in dystrophic mouse muscle, producing dystrophin and integrating with host nerves and blood vessels.

Ser149 is another potential 14-3-3 epsilon binding site of Cdc25B in the G2/M transition of mouse fertilized eggs

This study identifies Ser149 as a 14-3-3 epsilon binding site on Cdc25B, showing its role in regulating G2/M transition in mouse fertilized eggs through phosphorylation and subcellular localization.

Chemically induced partial unfolding of the multifunctional Apurinic/apyrimidinic endonuclease 1

This study investigates how the redox inhibitor APX3330 induces reversible partial unfolding of APE1, revealing structural changes relevant to its redox function.

High-quality nuclear genome and mitogenome of Bipolaris sorokiniana strain LK93, a devastating pathogen causing wheat root rot

The paper sequences and assembles the nuclear and mitochondrial genomes of Bipolaris sorokiniana strain LK93 to improve understanding of its interaction with wheat.

Cataloguing and profiling of the gut virome in Chinese populations uncover extensive viral signatures across common diseases

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

Drug degradation caused by mce3R mutations confers contezolid (MRX-I) resistance in Mycobacterium tuberculosis

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

HIV positive patients on antiretroviral therapy have an altered mucosal intestinal but not oral microbiome

This study compares the intestinal and oral microbiome composition and function between HIV-positive and uninfected individuals, finding significant intestinal changes but no oral differences.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model

This study uses CRISPR to correct dystrophin mutations in DMD patient-derived PSCs, revealing impaired Ca2+ handling and showing rescue through gene correction.

Dystrophin regulates peripheral circadian SRF signalling

This study shows dystrophin loss disrupts the RhoA-actin-SRF pathway, leading to circadian dysregulation in muscle and peripheral tissues.

Integrated Multi-Omics Data Reveals the Molecular Subtypes of Prostate Cancer

This study identifies molecular subtypes of prostate cancer using multi-omics data and clustering algorithms, revealing distinct clinical and biological features associated with each subtype.

Multi-omics consensus ensemble refines the classification of muscle-invasive bladder cancer with stratified prognosis, tumour microenvironment and distinct sensitivity to frontline therapies

This paper refines muscle-invasive bladder cancer classification using multi-omics data, identifying four subtypes with distinct prognoses and therapeutic responses.

Monotreme middle ear is not primitive for Mammalia

The paper challenges the hypothesis that the monotreme middle ear is primitive for mammals by critiquing the analysis and terminology used in a previous study.

Enzyme catalysis prior to aromatic residues: reverse engineering of a dephosphoCoA kinase

This study shows that enzyme catalysis can occur without aromatic amino acids by testing variants of dephosphoCoA kinase with reduced amino acid alphabets.

ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1

The paper shows that ATF-4 and hydrogen sulfide signaling mediate longevity from translation or mTORC1 inhibition in C. elegans.

Integrative Analysis the characterization of peroxiredoxins in pan-cancer

This study systematically analyzes peroxiredoxins (PRDXs) across 33 cancer types, examining expression, genetic alterations, methylation, prognosis, pathways, and drug targets, with validation of PRDX6's role in bladder cancer cell proliferation via JAK2-STAT3 pathway.

Global Profiling of the Lysine Crotonylome in Different Pluripotent States

This study profiles protein crotonylation in different mouse pluripotent states, identifying 3628 sites and showing that crotonyl-CoA promotes proteasome activity and delays differentiation.

Tumor Immunity Microenvironment-based classifications of bladder cancer for enhancing cancer immunotherapy

This study classifies bladder cancer patients into immune and non-immune groups using NMF and NTP algorithms, finding immune-activated patients respond better to anti-PD-1 therapy.

Multi-Task Learning based 3-Dimensional Striatal Segmentation of MRI - a Multi-modal Objective Assessment

This paper applies multi-task learning to automate 3D striatal segmentation in MRI, achieving results comparable to manual segmentation with high Dice similarity and correlation metrics.

Androgen Receptor promotes renal cell carcinoma (RCC) vasculogenic mimicry (VM) via altering TWIST1 nonsense-mediated decay through lncRNA-TANAR

Immune Response Drives Outcomes in Prostate Cancer: Implications for Immunotherapy

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

Effects of rhein on bile acid homeostasis in rats

This study examines the effects of rhein on bile acid homeostasis in rats, showing dose-dependent changes in bile acid levels and transporter expression without liver or kidney toxicity.

Prevention of enteric bacterial infections and modulation of gut microbiota composition with conjugated linoleic acids producing Lactobacillus in mice

This study shows that the probiotic Lactobacillus casei strain LC+mcra reduces Salmonella and EHEC infections in mice by modulating gut microbiota composition and improving gut health.