Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans
J. N. Pitt, E. Chavez, K. M. Provencher, M. Chen, C. Tran, J. Tran, K. Huang, A. Vaid, M. L. Abadir, N. Arang, S. F. Leiser, M. B. Roth, M. Kaeberlein
This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.
bioRxiv · Oct 13, 2022 · PreprintPhysiology