Author

E. Chavez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Douam· 2 shared A. B. Balazs· 1 shared A. Emili· 1 shared A. J. Trachtenberg· 1 shared A. K. O'Connell· 1 shared A. Klose· 1 shared A. Ploss· 1 shared A. R. Berneshawi· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioengineering

F. Douam

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA

J. E. McGee, J. R. Kirsch, D. Kenney, E. Chavez, T.-Y. Shih, F. Douam, W. W. Wong, M. W. Grinstaff

This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.

bioRxiv · Sep 15, 2023Bioengineering

Intermittent hypoxia therapy engages multiple longevity pathways to double lifespan in C.elegans

J. N. Pitt, E. Chavez, K. M. Provencher, M. Chen, C. Tran, J. Tran, K. Huang, A. Vaid, M. L. Abadir, N. Arang, S. F. Leiser, M. B. Roth, M. Kaeberlein

This study shows intermittent hypoxia therapy doubles C. elegans lifespan without HIF-1 but requires DAF-16/FOXO and other phosphatidylinositol signaling components.

bioRxiv · Oct 13, 2022 · PreprintPhysiology

Macrophages govern antiviral responses in human lung tissues protected from SARS-CoV-2 infection

D. J. Kenney, A. K. O'Connell, J. Turcinovic, P. Montanaro, R. M. Hekman, T. Tamura, A. R. Berneshawi, T. R. Cafiero, S. Al Abdullatif, B. Blum, S. I. Goldstein, B. Heller, H. P. Gertje, E. Bullitt, A. J. Trachtenberg, , F. Douam

This study shows that macrophages mediate antiviral responses in human lung tissues, protecting against SARS-CoV-2 infection through the USP18-ISG15 axis.

bioRxiv · Jul 17, 2021 · PreprintMicrobiology

The dental calculus metabolome in modern and historic samples

I. M. Velsko, K. A. Overmyer, C. Speller, M. Collins, L. Loe, L. A. F. Frantz, J. B. Rodriguez Martinez, E. Chavez, L. Klaus, K. Sankaranarayanan, C. M. Lewis, J. J. Coon, G. Larson, C. Warinner

This study characterizes the metabolome of modern and historic dental calculus to identify patterns of metabolite persistence and loss over time.

bioRxiv · May 9, 2017Microbiology