NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density
V. Somasundaram, L. A. Ridnour, R. Y. S. Cheng, A. J. Walke, N. Kedei, D. D. Bhattacharyya, A. L. Wink, E. F. Edmondson, D. Butcher, A. Warner, T. H. Dorsey, D. A. Scheiblin, W. Heinz, R. J. Bryant, R. Kinders, , D. A. Wink
This paper shows that blocking NOS2 and COX2 reduces TNBC tumor growth and improves CD8+ T cell infiltration and spatial distribution in tumors.
bioRxiv · Jun 3, 2022 · PreprintCancer Biology