CK2 signaling from TOLLIP-dependent perinuclear endosomes is an essential feature of KRAS and NRAS mutant cancers
S. Basu, B. Luke, B. Karim, N. Martin, S. Lockett, S. Das, T. Andresson, K. Saylor, S. Kozlov, L. Bassel, D. Esposito, M. Galloux, P. F. Johnson
This study identifies TOLLIP as a critical adaptor for CK2 signaling from perinuclear endosomes in KRAS and NRAS mutant cancers, showing its role in tumor proliferation and progression.
bioRxiv · Apr 5, 2022 · PreprintCancer Biology