Cancer BiologybioRxivPreprint
The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation
M. Moore, L. Pardo, L. Mitchell…·J. C. Norman
The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.
DOI 10.1101/2023.08.16.553544