M. Moore

Uridine Phosphorylase-1 supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes of the lung

White adipose tissue remodeling in Little Brown Myotis (Myotis lucifugus) with white-nose syndrome

This study compares white adipose tissue lipid composition between WNS-susceptible and resistant bat species, finding differential lipid profiles and WAT remodeling in infected susceptible bats.

Metabolic adaptations of micrometastases alter EV production to generate invasive microenvironments

The paper shows that breast cancer micrometastases alter metabolism to change extracellular vesicle production, creating an invasive microenvironment.

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

The paper analyzes copy number alterations in breast epithelial cells from BRCA mutation carriers and wildtype individuals, finding lineage-specific CNAs that mirror cancer genomes.

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

Conserved cold tolerance of Rhagoletis species from different host fruits, elevations in Colorado, USA

This study examines cold tolerance in two Rhagoletis species from different host fruits and elevations, finding conserved supercooling points and survival at low temperatures.

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

The eIF4A2 negative regulator of mRNA translation promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiation

The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.

The pore-forming apolipoprotein APOL7C drives phagosomal rupture and antigen cross-presentation by dendritic cells

This study identifies APOL7C as a pore-forming protein that facilitates phagosomal rupture and antigen cross-presentation by cDC1s.

Dynamics of mRNA fate during light stress and recovery: from transcription to stability and translation

The paper investigates how mRNA stability, transcription, and translation change during light stress and recovery in Arabidopsis thaliana, finding transcript destabilisation during stress and stabilisation during recovery.

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

This study identifies how GBM extracellular vesicles containing podocalyxin promote astrocyte hyaluronic acid deposition, enhancing GBM invasiveness.

Retrograde Control of Cytosolic Translation Targets Synthesis of Plastid Localized Proteins and Nuclear Responses for Efficient Light Acclimation.

The paper identifies a translation-dependent retrograde signaling pathway that regulates chloroplast protein synthesis and nuclear responses to light acclimation.

Dynamics and turnover of memory CD8 T cell responses following yellow fever vaccination

This study uses mathematical models to show that memory CD8 T cells decline following a power law, with division rates stabilizing and death rates declining slowly over decades.

Capturing in-field root system dynamics with the RootTracker

The paper introduces RootTracker, a device that measures root growth in the field, and finds that maize hybrids respond differently to drought by growing more and deeper roots.

Swimming direction of the glass catfish is responsive to magnetic stimulation

This study shows that glass catfish change their swimming direction in response to magnetic fields, demonstrating sensitivity and adaptability to magnetic stimuli.

Disentangling Sources of Gene Tree Discordance in Phylogenomic Datasets: Testing Ancient Hybridizations in Amaranthaceae s.l.

The paper investigates gene tree discordance in Amaranthaceae s.l. using multiple methods, finding that ancient hybridizations and rapid lineage diversification may contribute to the discordance.

Nectar-dwelling microbes of common tansy are attractive to its mosquito pollinator, Culex pipiens L.

The paper identifies microbes in common tansy nectar and shows that Lachancea thermotolerans attracts Culex pipiens mosquitoes through its odorants, which vary with culture medium composition.

Differences in Activation of Intracellular Signalling in Primary Human Retinal Endothelial Cells Between Isoforms of VEGFA-165.

This study compares the activation of MAPK and AKT signaling pathways by VEGFA165a and VEGFA165b in primary human retinal endothelial cells, finding stronger activation by VEGFA165a at lower doses.

Syndecan-1 facilitates breast cancer metastasis to the brain

This study shows that syndecan-1 promotes breast cancer metastasis to the brain by enhancing cell migration across the blood-brain barrier and altering cytokine secretion.

Reconstructing and Analysing The Genome of The Last Eukaryote Common Ancestor to Better Understand the Transition from FECA to LECA.

This study reconstructs the LECA genome using modern eukaryotic genomes and identifies key gene gains and functional changes during the FECA-to-LECA transition.

Ribosomal stress-induced senescence as a novel pro-senescence strategy for p16 positive basal-like breast cancer

This study identifies ribosomal proteins as pro-senescence targets in p16 positive basal-like breast cancer, showing their role in inducing stable cell cycle arrest and poor prognosis.

Disparity, Diversity, And Duplications In The Caryophyllales

The paper maps whole genome duplications (WGDs) and diversification shifts in Caryophyllales, finding some correlations but no tight link between WGDs and diversification rates.

Improved Transcriptome Sampling Pinpoints 26 Paleopolyploidy Events In Caryophyllales, Including Two Paleo-Allopolyploidy Events

The paper identifies 26 paleopolyploidy events in Caryophyllales, including two paleo-allopolyploidy events, using dense transcriptome and genome sampling and novel analytical methods.