Engagement of sialylated glycans with Siglec receptors on myeloid suppressor cells inhibit anti-cancer immunity via CCL2
R. Wieboldt, E. Carlini, L. Chia-wei, A. Boersch, A. Zingg, D. Lardinois, P. Herzig, L. Don, A. Zippelius, H. Laeubli, N. Rodrigues Mantuano
This study shows that sialylated glycans on myeloid suppressor cells interact with Siglec receptors to suppress anti-cancer immunity through CCL2-mediated mechanisms.
bioRxiv · Jun 29, 2023 · PreprintImmunology