K. Fischer

Nucleocapsid condensation drives Ebola viral factory maturation and dispersion

This study uses cryo-ET to show that Ebola virus nucleocapsids transition from loose helical structures to condensed cylinders, driving viral factory maturation and dispersion.

Dynamic control of gene expression by ISGF3 and IRF1 duringIFNbeta and IFNgamma signaling

The paper shows that IFN-I and IFN-gamma produce distinct transcriptomes over time due to different roles of ISGF3 and IRF1 in enhancer activation and chromatin accessibility.

Vgamma9+Vdelta2+Tcell-mediated purging of Listeria monocytogenes-infected epithelial cells requires butyrophilin 3A genes

The paper shows that Vgamma9+Vdelta2+ T cells purge Listeria monocytogenes-infected epithelial cells via BTN3A1 and BTN3A3, with BTN3A3 possibly presenting different antigens.

Highly pathogenic avian influenza causes mass mortality in Sandwich tern (Thalasseus sandvicensis) breeding colonies across northwestern Europe

This study reports mass mortality of Sandwich terns due to HPAI A(H5N1) in northwestern Europe, with over 17% of the breeding population dying and high chick mortality observed.

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

Cross-species analysis identifies conserved transcriptional mechanisms of neutrophil maturation

The paper identifies conserved transcriptional mechanisms of neutrophil maturation across zebrafish, mouse, and human by generating high-resolution transcriptional profiles and cross-species comparisons.

A translational swine model for Crohn`s disease

This paper develops a genome-edited swine model of Crohn's disease that replicates key human disease features to enable translational research.

Wireless closed-loop smart bandage for chronic wound management and accelerated tissue regeneration

This paper develops a wireless smart bandage that monitors wound conditions and delivers electrical stimulation to accelerate tissue regeneration in chronic wounds.

Isolation and characterization of a novel Wolbachia bacteriophage from Allonemobius socius crickets in Missouri

The paper isolates and characterizes a novel Wolbachia bacteriophage from crickets in Missouri, providing the first whole-genome sequence of phage WO from this species outside Asia.

MTX-COVAB, a human-derived antibody with potent neutralizing activity against SARS-CoV-2 infection in vitro and in a hamster model of COVID-19

The paper identifies a human-derived monoclonal antibody, MTX-COVAB, with potent neutralizing activity against SARS-CoV-2 in vitro and in a hamster model, showing efficacy against variants and readiness for clinical testing.

Porcine model elucidates function of p53 isoform in carcinogenesis

This study uses a porcine model to show that specific p53 isoforms and circular TP53 RNA drive tumorigenesis, particularly osteosarcoma, in pigs and likely have similar roles in humans.

Machine learning reveals time-varying microbial predictors with complex effects on glucose regulation

This study uses machine learning to identify gut microbiome predictors of glucose regulation and T2D risk using longitudinal data from a Finnish cohort.

Evidence for dual targeting of Arabidopsis plastidial glucose-6-phosphate transporter GPT1 to peroxisomes via the ER

The paper shows GPT1 in Arabidopsis is dual-targeted to plastids and peroxisomes via the ER, explaining its unique functions compared to GPT2.

In vitro activity of beauvericin against all developmental stages of Sarcoptes scabiei

This study evaluates the acaricidal activity of beauvericin against different life stages of Sarcoptes scabiei and compares it to dimpylate and ivermectin, showing higher efficacy and low toxicity to human fibroblasts.

Kunitz type protease inhibitor EgKI-1 from the canine tapeworm Echinococcus granulosus as a promising anti-cancer therapeutic

This study identifies EgKI-1, a protease inhibitor from Echinococcus granulosus, as a potential anti-cancer agent that inhibits cancer cell growth and migration in vitro and reduces tumor growth in vivo.