Lipid-mediated dimerization of membrane-anchored c-Src is driven by a cluster of lysine residues in the N-terminal SH4 domain.
I.-L. Mohammad, J. Carvajal, A. Fernandez…·M. Pons
This study identifies a cluster of lysine residues in the SH4 domain of c-Src that enhances lipid-mediated dimerization, increasing tyrosine phosphorylation in HEK293T cells.