M. Pons

Induction of the inflammasome by the SARS-CoV-2 accessory protein ORF9b, abrogated by small-molecule ORF9b homodimerization inhibitors

This study shows that SARS-CoV-2's ORF9b protein activates inflammasomes and caspase-1, and small molecules inhibiting its homodimerization reduce inflammation and restore interferon signaling.

Modulation of functional phosphorylation sites by basic residues in the Unique domain of c-Src

The paper investigates how basic residues modulate phosphorylation sites in the SNRE of c-Src using NMR and mutations, revealing electrostatic interactions and their effects on conformation.

The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

Sea lamprey nests promote the diversity of benthic macroinvertebrate assemblages

The paper examines how sea lamprey nests affect benthic macroinvertebrate diversity and traits, finding increased overall diversity in nest areas compared to control zones.

Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

Lipid-mediated dimerization of membrane-anchored c-Src is driven by a cluster of lysine residues in the N-terminal SH4 domain.

This study identifies a cluster of lysine residues in the SH4 domain of c-Src that enhances lipid-mediated dimerization, increasing tyrosine phosphorylation in HEK293T cells.

NOXA expression drives synthetic lethality to RUNX1 inhibition in pancreatic cancer

The paper identifies RUNX1 inhibition as a strategy to induce NOXA-dependent apoptosis in pancreatic cancer, showing it blocks tumor growth in vivo and in organoids.

Regulation of Src tumor activity by its N-terminal intrinsically disordered region

This study identifies the ULBR in Src as essential for its oncogenic activity by modulating membrane substrate phosphorylation.

The systemic activin response to pancreatic cancer: Implications for effective cancer cachexia therapy

This study shows that pancreatic cancer induces a systemic activin response contributing to cachexia, and that targeting both tumor and host-derived activins may improve therapy.