BioengineeringbioRxivPreprint
IgG-inspired, multivalent protein-DNA nanostructures for high-affinity, tunable, and reversible binding to biomolecular targets
Rong Zheng, Yang Xu, Abhay Prasad…·Nicholas Stephanopoulos
This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.