Hao Yan

This paper introduces a method to create complex RNA nanostructures with over 100 unique components using dsRNA bricks, overcoming limitations of RNA scalability and stability.

This paper develops a DNA-templated chiral metamaterial array for secure optical information storage using plasmonic chirality to encode binary data.

This paper demonstrates DNA branch migration across lipid membranes to detect intracellular RNA without lysing cells, using a synthetic GPCR-like system called HALOS.

This paper introduces a DNA-based data storage method using epigenetic modifications, achieving scalable and parallel data writing and retrieval.

This paper introduces DNA-templated PROTACs (DTACs) that enable precise spatial control over protein degradation, showing enhanced selectivity and potency in degrading the CyclinD1-CDK4/6 complex.

This paper demonstrates the site-specific arrangement and structural determination of minor groove binding molecules in self-assembled DNA crystals using x-ray crystallography.

This paper designs and tests a DNA-based synthetic antibody (nano-synbody) that binds SARS-CoV-2 spike proteins with high affinity and reversibility through multivalency.