Stress granule component TIA-1 is a specific negative regulator of the non-canonical NLRP3 inflammasome.
Prem Prasad Lamichhane, Aditi Aditi, Blake H. Neil…·Parimal Samir
This study identifies TIA-1 as a negative regulator of the non-canonical NLRP3 inflammasome, showing its role in suppressing LPS-induced inflammation and endotoxic shock.