Louis Boon

This study shows that autophagy in lymphatic endothelial cells promotes lung metastasis by altering lymphatic pathways and immune niches.

This study shows copper chelation enhances immune checkpoint blockade therapy in mesothelioma by altering the tumour microenvironment and increasing cytotoxic lymphocytes.

This study shows that chronic elevation of interferon-alpha drives a specific immune endotype of Sjogren disease, detectable up to 14 years before diagnosis.

The paper identifies CSF1 and TGFβ as key signals for synovial lining macrophage development in mice, which occurs postnatally and is monocyte-independent.

This study shows that RNA editing of FLNA in myeloid cells reduces intestinal inflammation and protects against colitis in mice and humans.

The paper identifies Mgl2+ cDC2s as key drivers of type 2, but not type 17, fungal allergic airway inflammation in mice.

This study shows PD-L1 blockade in tumor-bearing mice targets bone marrow HSPCs, reprograms their transcriptome toward inflammation, and reduces myeloid-derived suppressor cells.

This study identifies a regulatory pathway between BTLA and CD5 in T cells that calibrates their expression to establish self-tolerance in recent thymic emigrants.

This study shows trabectedin enhances oncolytic virotherapy by reducing anti-viral barriers and boosting immune-mediated tumor regression in preclinical models.

This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.