Cancer BiologybioRxiv
CDK19 and CDK8 Mediator kinases drive androgen-independent in vivo growth of castration-resistant prostate cancer
Jing Li, Thomas A. Hilimire, Yueying Liu…·Mengqian Chen
This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.
DOI 10.1172/jci176709