Author
University of South CarolinaORCID 0000-0003-1706-9509Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
George Merhej, Gurusankar Ramamoorthy, Danda P. Chapagai…·Campbell McInnes
This study develops and characterizes abbapolins, non-peptidic PLK1 PBD inhibitors, showing in vivo efficacy against prostate cancer and synergy with enzalutamide.
Manikanda Raja Keerthi Raja, Gourab Gupta, Grace Atkinson…·Hexin Chen
This study shows that host-derived IL-1α promotes an immunosuppressive tumor microenvironment by regulating monocyte-to-macrophage differentiation in breast cancer.
Mehri Monavarian, Resha Rajkarnikar, Emily Faith Page…·Karthikeyan Mythreye
This study shows CDK8/19 inhibition can reverse anoikis resistance and metastasis in ovarian cancer by altering transcriptional programs.
Alexandra V. Bruter, Ekaterina A. Varlamova, Nina I Stavskaya…·Victor Vyacheslavovich Tatarskiy
This study shows that systemic knockout of Cdk8 and Cdk19 in mice leads to infertility due to depletion of cyclin C and impaired spermatogenesis, suggesting kinase-independent functions of CDK8/19.
Alvina I. Khamidullina, Margarita A. Yastrebova, Alexandra V. Bruter…·Victor Vyacheslavovich Tatarskiy
This study shows that CDK8/19 inhibition overcomes BCR-ABL inhibitor-induced G1 arrest and promotes apoptosis in CML cells.