Mechano-activation of synovial fibroblasts and macrophages during OA progression in the dynamically stiffening synovial microenvironment
Sung Yeon Kim, Easton C. Farrell, Kevin G. Burt, Bryan Kwok, Qiushi Liang, Alexander J. Knights, Kate L. Sharp, Vu Nguyen, Lance A. Murphy, Baofeng Hu, Alexandra Kahn, Ling Qin, Lin Han B, Tristan Maerz, Rob Mauck, Carla R. Scanzello
This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.
bioRxiv · Feb 18, 2026 · PreprintBioengineering