Kevin G. Burt

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

This study shows CD14-deficiency protects against osteoarthritis-related subchondral bone sclerosis by enhancing osteoclastogenesis post-injury in mice.

This study shows HMGB1 promotes macrophage recruitment and worsens intervertebral disc degeneration after injury, with knockout mice showing reduced mechanical and structural damage.

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.