Robert L. Mauck

This study shows that denervation in neonatal mice impairs musculoskeletal growth, altering cell proliferation and mechanotransduction gene programs in tendons and muscles.

This study shows that altering synovial cell mechanotransduction drives OA-like disease without joint injury, with partial effects on symptoms versus structural damage.

This study identifies decorin-mediated extracellular matrix stabilization as a key factor in maintaining cartilage integrity during aging, showing its role in preventing age-associated osteoarthritis.

This study shows decorin strengthens collagen II-aggrecan integration in cartilage matrix, reducing aggrecan loss and supporting its therapeutic potential for osteoarthritis.

This study shows that the Acvr1R206H mutation in FOP remodels chromatin through BMP-SMAD and Rho/ROCK signaling, driving aberrant osteogenesis, and identifies reversible chromatin changes as a therapeutic target.

This study uses FLARE-ExM to examine changes in tendon cellular and extracellular structures under healthy and perturbed conditions, revealing structural alterations in response to mechanical stress.

The study shows CD14 is critical for pain and inflammation in post-traumatic osteoarthritis and that blocking CD14 can reduce pain and mobility loss.

This study investigates how synovial microenvironment stiffness changes during OA progression and how it affects fibroblast and macrophage behavior through mechanosignaling and cell-cell interactions.

This study shows CD14-deficiency protects against osteoarthritis-related subchondral bone sclerosis by enhancing osteoclastogenesis post-injury in mice.

This study shows that transient nuclear softening with TSA treatment enhances cell migration and matrix formation in porcine meniscal cells, with full restoration of transcriptional phenotype and function within 7 days.

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.

O-SNAP extracts and classifies chromatin features from SMLM data, detecting subtle changes in chromatin organization across biological transitions.

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

This paper develops a tunable hydrogel system using decellularized meniscus extracellular matrix to repair zonal-specific meniscal injuries, showing improved cell differentiation and tissue integration.

This paper describes an outreach module designed to engage high school students in orthopaedic research, showing significant learning gains and increased interest in the field.

This study develops a bicontinuous hydrogel system that enables rapid 3D cell migration by leveraging microinterfaces, showing mesenchymal behavior across multiple contexts.

This study tracks meniscus maturation in mice, showing that specialized cellular and matrix features emerge before birth and are refined during postnatal growth.

This study identifies Gli1+ cells as a progenitor population in meniscus development and injury repair, showing their therapeutic potential in preventing osteoarthritis.