Andrew Tsourkas

This study shows that sPLA2 inhibitor-loaded nanoparticles reduce spontaneous osteoarthritis in guinea pigs by decreasing cartilage damage and inflammation.

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

This study shows that DSPE-PEG fails to retain mAbs on LNPs in vivo, while a higher molecular weight PCL-b-PEG anchor maintains stability, highlighting the importance of anchoring strength for extrahepatic delivery.

This study uses multimodal imaging and transcriptomics to show increased reactive oxygen species activity in myocardial tissue and systemic organs after myocardial infarction, with associated gene expression changes.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

This study develops Cy3-PLGA nanoparticles that restore lysosomal pH and function in retinal pigment epithelial and astrocyte cells, showing sustained delivery and retention for at least 28 days.