Ang Li

Aldh3a1-mediated detoxification of reactive aldehydes contributes to distinct muscle responses to Amyotrophic Lateral Sclerosis progression

This study identifies Aldh3a1's role in protecting muscles from ALS progression by detoxifying reactive aldehydes, showing differential expression and functional importance across muscle types.

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

PI-FC: Pre-training Individual-specific Functional Connectome through State-invariant Contrastive Learning

PI-FC uses state-invariant contrastive learning to extract stable individual brain signatures from fMRI, improving phenotypic prediction accuracy and reducing scanning time across multiple datasets.

Somatic repetitive element insertions Define New Biomarkers in Pan-cancer genome

This study identifies somatic repetitive element insertions as new biomarkers in pan-cancer by analyzing 325 cancer genomes using long-read sequencing.

Longevity or Well-being? A Dual-Dimension Structure of Neuroticism

The paper proposes that neuroticism variability can be structured into two dimensions, one linked to longevity and the other to well-being, with distinct neural and genetic underpinnings.

Integrated fragmentomic profile and 5-Hydroxymethylcytosine of capture-based low-pass sequencing data enables pan-cancer detection via cfDNA

The paper develops an integrated model using fragmentomic and 5-hydroxymethylcytosine features from low-pass sequencing data to achieve high sensitivity and specificity in pan-cancer detection.