Cell BiologybioRxiv
Cardiac Troponin I Directly Binds and Inhibits Mitochondrial ATP Synthase: a Noncanonical Role in the Post-Ischemic Heart
A. Elezaby, A. J. Lin, V. Vijayan…·D. Mochly-Rosen
This study identifies a noncanonical role of cardiac troponin I in inhibiting mitochondrial ATP synthase, showing that blocking this interaction reduces cardiac injury during ischemia.
DOI 10.1038/s44161-024-00512-1