B. Dutta

Macrophage microRNA-146a is a central regulator of the foreign body response to biomaterial implants

This study identifies miR-146a as a key regulator of the foreign body response to biomaterial implants, showing its role in macrophage function, fibrosis, and FBGC formation.

Thiosulfinate tolerance gene clusters are common features of Burkholderia onion pathogens.

This study identifies thiosulfinate tolerance gene clusters in onion-associated Burkholderia species and shows their role in allicin tolerance and growth in onion extracts.

Ginsentide TP1 Protects Hypoxia-Induced Dysfunction and ER Stress-Linked Apoptosis

This study shows ginsentide TP1 protects human endothelial cells from hypoxia-induced dysfunction and ER stress-linked apoptosis by restoring NO signaling, reducing oxidative stress, and preventing endothelial activation.

Decoding the Cure-all Effects of Ginseng

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

The genetic requirements for HiVir-mediated onion necrosis by Pantoea ananatis, a necrotrophic plant pathogen

This study identifies the genetic requirements for HiVir-mediated onion necrosis in Pantoea ananatis, showing that hvrB-hvrF are essential while hvrG-hvrJ are partially required, and highlights SNPs in deviant strains.

Toxicological Analysis of Poly-Lactide Co-Glycolide Microparticles, Chitosan Nanoparticles and Poly(Anhydride) Nanoparticles in Vero Cell

The paper evaluates the in vitro cytotoxicity of chitosan nanoparticles, poly(anhydride) nanoparticles, and PLG microparticles on Vero cells, finding that PLG microparticles at 1000 g/ml reduced cell viability, while others were safe at lower concentrations.

A novel biosynthetic gene cluster across the Pantoea species complex is important for pathogenicity in onion

This study identifies two phosphonate biosynthetic gene clusters in Pantoea species causing onion pathogenicity, with the novel Halophos cluster contributing to necrosis.

The distribution of onion virulence gene clusters among Pantoea spp.

The paper assesses the distribution of HiVir and alt virulence gene clusters in Pantoea spp. using PCR and RSN assays, finding significant associations with pathogenicity in onion rot.

Pantoea ananatis defeats Allium chemical defenses with a plasmid-borne virulence gene cluster

This study identifies a plasmid-borne gene cluster in Pantoea ananatis that enables tolerance to allicin and other thiosulfinates produced by Allium plants, revealing a chemical arms race between the pathogen and host.