N. Feng

uORF-targeting steric block antisense oligonucleotides do not reproducibly activate RNASEH1 expression

The paper tests uORF-targeting ASOs for RNASEH1 upregulation but finds no reproducible activation, instead observing downregulation in some cases.

Evolutionary fingerprints of EMT in pancreatic cancers

This study investigates the role of EMT in pancreatic cancer evolution and metastasis, showing that mesenchymal lineages drive chromosomal instability and clonal evolution.

Decoding the Cure-all Effects of Ginseng

This study identifies ginsentides as active compounds in ginseng that restore homeostasis under stress by interacting with multiple physiological systems.

Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner

This study shows that MRTX1133, a KrasG12D inhibitor, reduces early pancreatic lesions and, when combined with immunotherapy, regresses advanced PDAC by enhancing CD8+ T cell activity.

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

Reduced acetylation of TFAM promotes bioenergetic dysfunction in the failing heart

This study shows that reduced GCN5L1 expression in the failing heart leads to mitochondrial dysfunction and decreased bioenergetic output.

Mucosal and systemic neutralizing antibodies to norovirus and rotavirus by oral immunization with recombinant rotavirus in infant mice

This paper demonstrates that oral immunization with a recombinant rotavirus expressing norovirus VP1 induces systemic and mucosal neutralizing antibodies against both rotavirus and norovirus in infant mice.

A recombinant murine rotavirus with Nano-Luciferase expression reveals tissue tropism, replication dynamics, and virus transmission

This paper develops a recombinant murine rotavirus expressing Nano-Luciferase to study tissue tropism, replication dynamics, and transmission in vivo.

Hand Gesture Prediction via Transient-phase sEMG using Transfer Learning of Dilated Efficient CapsNet: Towards Generalization for Neurorobotics

This paper proposes a dilated efficient capsular neural network with transfer learning for hand gesture prediction using sEMG signals, showing improved performance with limited individual data.

The bladder microbiome, metabolome, cytokines, and phenotypes in patients with systemic lupus erythematosus

This study examines the bladder microbiome, metabolome, and cytokines in SLE patients, finding associations between microbial composition and disease-related metabolites and cytokines.

Feasibility of Administering Human Pancreatic Cancer Chemotherapy in a Spontaneous Pancreatic Cancer Mouse Model

This study demonstrates the feasibility of administering clinical chemotherapy regimens, mFOLFIRINOX and gemcitabine/nab-paclitaxel, in a spontaneous pancreatic cancer mouse model, showing improved survival compared to controls.

A bacterium-like particle vaccine displaying Zika virus prM-E induces systemic immune responses in mice

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

Selective augmentation of intestinal immunity by CD22-dependent SHP-1 control of β7 integrin expression.

This study identifies CD22-dependent SHP-1 regulation of β7 integrin expression, showing its role in intestinal immunity and pathogen clearance.

Rotavirus re-programs multiple IFN receptors and restricts their intestinal antiviral and inflammatory functions

This study shows rotavirus reprograms IFN receptors to suppress antiviral and inflammatory responses in the intestine.