B. Hoffman

Evaluating Paraspinal Muscle Response and Compensation via Musculoskeletal Modeling in Spinal Stenosis Surgeries

This study compares muscle force changes in different spinal stenosis surgeries using musculoskeletal modeling, finding that laminotomy reduces muscle compensation compared to laminectomy.

Biomechanical Implications of Spinopelvic Alignment on Femoral Head Cartilage and the Proximal Femoral Physis in Slipped Capital Femoral Epiphysis: A Theoretical Finite Element Analysis

This study uses finite element analysis to show that posterior pelvic tilt and high pelvic incidence increase shear stress on the growth plate, potentially causing slippage in slipped capital femoral epiphysis.

Bcl-xL restricts transcriptional, morphological and functional decompensation of β-cell mitochondria under chronic glucose excess

This study shows that Bcl-xL prevents mitochondrial dysfunction in beta-cells under chronic glucose stress by limiting mitochondrial ROS and maintaining gene expression.

Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice

This study shows that H3K4me3 is essential for maintaining beta cell function in adult mice by supporting gene expression for insulin biosynthesis and glucose responsiveness.

A Molecular Tension Sensor for N-Cadherin Reveals Distinct Forms of Mechanosensitive Adhesion Assembly in Adherens and Synaptic Junctions

This study develops a FRET-based tension sensor for N-cadherin to analyze mechanosensitive adhesion assembly in adherens and synaptic junctions, revealing cell-type specific regulation and mechanosensitive signaling in neurons.