B. J. Lee

A Non-Canonical IRAK Signaling Pathway Triggered by DNA Damage

The paper identifies a non-canonical IRAK signaling pathway triggered by DNA damage that promotes anti-apoptosis and is activated by ionizing radiation and genotoxic therapies.

Allosteric SHP2 Inhibition Increases Apoptotic Dependency on BCL2 and Synergizes with Venetoclax in FLT3- and KIT- Mutant AML

This study shows that combining SHP2 and BCL2 inhibition synergistically kills FLT3- and KIT-mutant AML cells and xenografts.

Shaping nanoparticle diffusion through biological barriers to drug delivery

This study investigates how the shape of rod-shaped nanoparticles affects their diffusion through biological gels and identifies optimal dimensions for enhanced diffusion.

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination

This study shows that DNA-PKcs phosphorylation at T2609 cluster promotes cNHEJ repair pathway choice during CSR, as loss of this phosphorylation increases chromosomal translocation and alternative end-joining.

Generation of cell-free matrices that support human NK cell migration and differentiation

This study generates cell-derived matrices that support human NK cell migration and differentiation, showing they can replace intact stromal cells for in vitro NK cell development.

Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors

The paper tracks NK cell progenitors over weeks using phase-contrast microscopy, showing increased motility and heterogeneous migratory behaviors during differentiation.