Author

S. Zha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

B. J. Lee· 2 shared Z. Shao· 2 shared A. Glasgow· 1 shared A. Gorbatenko· 1 shared A. L. Belcher· 1 shared A. P. Wiita· 1 shared D. Limonta· 1 shared F. Nemati· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCell Biology

B. J. Lee

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Non-Canonical IRAK Signaling Pathway Triggered by DNA Damage

Y. Li, R. B. Shah, S. Sarti, A. L. Belcher, B. J. Lee, A. Gorbatenko, F. Nemati, I. Yu, Z. Stanley, Z. Shao, J. Silva, S. Zha, S. Sidi

The paper identifies a non-canonical IRAK signaling pathway triggered by DNA damage that promotes anti-apoptosis and is activated by ionizing radiation and genotoxic therapies.

bioRxiv · Feb 8, 2023 · PreprintCell Biology

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA

M.-F. Langelier, X. Lin, S. Zha, J. M. Pascal

This study shows clinical PARP inhibitors can allosterically retain PARP2 on DNA breaks, differing from their effect on PARP1, with implications for PARPi toxicity and design.

bioRxiv · Nov 8, 2022Biochemistry

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering

DNA-PKcs phosphorylation at the T2609 cluster alters the repair pathway choice during immunoglobulin class switch recombination

J. J. Crowe, X. Wang, Z. Shao, B. J. Lee, V. Estes, S. Zha

This study shows that DNA-PKcs phosphorylation at T2609 cluster promotes cNHEJ repair pathway choice during CSR, as loss of this phosphorylation increases chromosomal translocation and alternative end-joining.

bioRxiv · Apr 23, 2020Immunology