B. Joseph

Dynamic basis of lipopolysaccharide export by LptB2FGC

This study investigates how LptB2FG couples ATP binding and hydrolysis to LPS transport by analyzing conformational changes and interactions in the Lpt complex.

Lateral gating mechanism and plasticity of the BAM complex in micelles and E. coli

This study investigates the conformational dynamics of the BAM complex in micelles and E. coli, revealing that BamCDE regulates lateral gating in BamA.

Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding

This study investigates the structural and functional roles of appendage domains in Legionella pneumophila MIP proteins, revealing their impact on inhibitor binding and dynamics, and provides structural insights for developing pathogen-specific inhibitors.

In situ distance measurements in a membrane transporter using maleimide functionalized orthogonal spin labels and 5-pulse electron double resonance spectroscopy

The paper demonstrates the use of maleimide-functionalized spin labels and 5-pulse electron double resonance to measure distances in membrane proteins within native environments.

Skin specimen as an alternative to brain tissue for post mortem rabies diagnosis in animals to scale up animal rabies surveillance

This study evaluates the use of skin specimens as an alternative to brain tissue for post-mortem rabies diagnosis in animals, finding RT-PCR on skin to be sensitive and specific.

A neural m6A/YTHDF pathway is required for learning and memory in Drosophila

This study identifies the m6A/YTHDF pathway's role in learning and memory in Drosophila by mapping m6A sites and showing their impact on translation and neural function.

Live detection of neural stem and glioblastoma cells by an oligothiophene derivative

This study introduces p-HTMI, an oligothiophene derivative that selectively detects live human glioblastoma and neural stem cells in vitro and in vivo.

Structural basis for functional interactions in dimers of SLC26 transporters

The paper determines the structure of an SLC26 dimer in a lipid membrane and shows its functional relevance through combined experimental and computational methods.