Caffeine and MDMA (ecstasy) exacerbate ER stress triggered by hyperthermia
This study shows that caffeine and MDMA enhance ER stress and protein secretion caused by hyperthermia in a cellular model.
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3 papers
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This study shows that caffeine and MDMA enhance ER stress and protein secretion caused by hyperthermia in a cellular model.
L. K. Greer, K. G. Meilleur, B. K. Harvey, E. S. Wires
The paper identifies ER/SR resident proteins as potential biomarkers for ER/SR calcium depletion in skeletal muscle cells, showing that MANF and SEPN1 are elevated in extracellular samples and may correlate with disease progression.
K. A. Trychta, B. Xie, R. Verma…·B. K. Harvey
The paper develops a computational method to predict ER retention sequences that can undergo secretion during ER calcium depletion by analyzing non-canonical ERS sequences.