Author

B. Keith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

M. C. Simon· 2 shared N. Skuli· 2 shared A. Bakayoko· 1 shared A. D'Alessandro· 1 shared A. L. Good· 1 shared A. Matthews· 1 shared A. Raj· 1 shared A. Salimov· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

M. C. Simon

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemoresistance of TP53 mutant AML requires the mevalonate byproduct, GGPP, for regulation of ROS and induction of a mitochondria stress response

S. J. Skuli, A. Bakayoko, M. Kruidenier, B. Manning, P. Pammer, A. Salimov, O. Riley, G. Brake-Silla, M. Bowman, L. N. Martinez-Gutierrez, R. Buono, M. Paul, E. Saland, S. Wong, J. Xu, , M. Carroll

This study identifies GGPP, a mevalonate pathway byproduct, as critical for chemoresistance in TP53mut AML through ROS regulation and mitochondria stress response, suggesting statin-based therapies could be effective.

bioRxiv · Jun 7, 2024 · PreprintCancer Biology

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

K. A. Alexander, R. Yu, N. Skuli, N. J. Coffey, S. Nguyen, C. Faunce, H. Huang, I. Dardani, A. L. Good, J. Lim, C. Li, N. Biddle, E. F. Joyce, A. Raj, D. Lee, , S. L. Berger

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

bioRxiv · Sep 14, 2023 · PreprintCancer Biology

The Cdc42 effector and non-receptor tyrosine kinase, ACK defines a distinct STAT5 transcription signature in a chronic myeloid leukaemia cell model

J. Corry, D. Jachimowicz, B. Keith, J. J. Vicente-Garcia, H. R. Mott, K. Wickson, D. Owen

The paper shows ACK enhances STAT5 transcriptional activity in K562 cells and identifies an ACK-driven STAT5 signature, suggesting a therapeutic target in CML.

bioRxiv · Jun 10, 2022 · PreprintBiochemistry