K. Kleigrewe

This study shows that microbiota and metabolite rhythmicity develops early in life, influenced by diet and breastfeeding, with GOS-supplemented formula promoting bifidobacteria.

The paper uses untargeted metabolomics to identify PTI-associated metabolites in tomato plants responding to fungal elicitors and pathogens.

The paper shows that secondary bile acids from gut bacteria worsen colorectal cancer in a Western diet model.

This study shows that altering meal timing (restricted feeding) can restore intestinal clock function and reduce inflammation in IBD models.

The paper identifies keystone species in a synthetic gut bacterial community and shows their roles vary with nutritional and host environments.

The paper shows that phages targeting protective gut bacteria increase susceptibility to Salmonella Typhimurium infection in gnotobiotic mice.

This study shows that circadian disruption from genetic and environmental factors causes metabolic issues by altering gut microbiome function and rhythmicity.

This study shows that the host's intestinal circadian clock regulates microbial rhythms, maintaining gut homeostasis through metabolite production and immune system modulation.

This study investigates the interaction network of a synthetic gut bacterial community, revealing exploitative and interference competition shaping community dynamics.