Author

B. Loh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 2 Organism:C. elegans· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:Arabidopsis· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

S. Leptihn· 7 shared P. Manohar· 4 shared R. Nachimuthu· 4 shared L. Ma· 2 shared X. Hua· 2 shared A. Loganathan· 1 shared D. Turner· 1 shared E. Namasivayam· 1 shared

Activity by Year

2020-2022 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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7 shared papersMicrobiology

S. Leptihn

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Author profile →

7 papers

Recent·Most cited

In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy

P. Manohar, B. Loh, D. Turner, T. Ramasamy, M. Mathankumar, N. Elangovan, R. Nachimuthu, S. Leptihn

This paper evaluates the Pseudomonas phage Motto for its ability to degrade biofilms and treat P. aeruginosa infections in vitro and in vivo, finding it effective against biofilm-producing isolates and safe in human cell lines.

bioRxiv · Oct 12, 2022 · PreprintMicrobiology

From motor protein to toxin: Mutations in the zonula occludens toxin (Zot) of Vibrio cholerae phage CTXΦ suggest a loss of phage assembly function

L. Ma, S. Roux, X. Hua, Y. Wang, B. Loh, S. Leptihn

The paper investigates mutations in the Zot toxin of Vibrio cholerae phage CTXΦ, showing that these mutations impair phage assembly and suggest a shift in Zot's function to an auxiliary toxin.

bioRxiv · Sep 21, 2022 · PreprintMicrobiology

Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms

P. Manohar, B. Loh, R. Nachimuthu, S. Leptihn

This study evaluates phage-antibiotic/antifungal combinations against single- and dual-species biofilms of P. aeruginosa and C. albicans, finding some synergistic effects but limited efficacy against dual-species biofilms.

bioRxiv · Aug 18, 2022Microbiology

A Lysozyme Murein Hydrolase with Broad-spectrum Antibacterial Activity from Enterobacter Phage myPSH1140

R. Nachimuthu, P. Manohar, K. Eniyan, L. Archana, S. Athira, B. Loh, L. Ma, S. Leptihn

This study characterizes Gp105, a lysozyme murein hydrolase from Enterobacter phage myPSH1140, showing broad-spectrum antibacterial activity against Gram-negative pathogens.

bioRxiv · Apr 6, 2022Microbiology

A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens

P. Manohar, B. Loh, E. Namasivayam, A. Loganathan, R. Nachimuthu, S. Leptihn

This paper develops a C. elegans assay to evaluate phage efficacy against clinical pathogens, showing improved survival rates with phage treatment.

bioRxiv · Jan 5, 2022Microbiology

Phage Resistance Mechanisms Increase Colistin Sensitivity in Acinetobacter baumannii

X. Wang, B. Loh, Y. Yu, X. Hua, S. Leptihn

This study shows that phage resistance mechanisms in A. baumannii reduce colistin resistance by altering bacterial envelope structure, increasing antibiotic sensitivity.

bioRxiv · Jul 23, 2021Microbiology

Characterisation of bacteriophage JD419, a Staphylococcal phage with an unusual morphology and broad host range

T. Feng, S. Leptihn, K. Dong, B. Loh, Y. Zhang, M. Li, X. Guo, Z. Cui

This paper characterizes bacteriophage JD419, which has a broad host range and retains lytic activity under various conditions, and reports its genome lacking virulence or antibiotic resistance genes.

bioRxiv · Nov 9, 2020 · PreprintMicrobiology