Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogramming
Y. Wang, G. Li, B. Chen, G. Shakir, M. Volz, E. van der Vorst, S. Maas, C. Muley, A. Bartelt, Z. Li, N. Sachs, L. Maegdefessel, M. Nazari Jahantigh, M. Hristov, M. Lacy, , S. Steffens
This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.
bioRxiv · Apr 6, 2023 · PreprintImmunology