A. Bartelt

Control of cholesterol-induced adipocyte inflammation by the Nfe2l1-Atf3 pathway

This study identifies the Nfe2l1-Atf3 pathway as a regulator of cholesterol-induced adipocyte inflammation and insulin resistance in both human and mouse models.

Macroscopic label-free biomedical imaging withshortwave infrared Raman scattering

This paper introduces a shortwave infrared Raman imaging technique that enables label-free, high-contrast visualization of tissue composition and pathology without contrast agents.

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice

This study shows chronic intermittent fasting impairs β-cell maturation and function in adolescent mice, but not in adults, with similar patterns observed in human type 1 diabetes.

IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat

This paper identifies IF1 as a cold-regulated inhibitor of ATP synthase that facilitates reverse mode activity in brown fat to support thermogenesis.

The myocyte Nfe2l1-ubiquitin-proteasome system controls muscle fiber type and obesity-induced insulin resistance

This study shows that Nfe2l1 regulates skeletal muscle proteostasis and function, with its loss causing muscle fiber type switching and insulin resistance in high-fat diet conditions.

Loss of myeloid cannabinoid CB1 receptor confers atheroprotection by reducing macrophage proliferation and immunometabolic reprogramming

This study shows that loss of myeloid CB1 receptor reduces atherosclerosis in male mice by limiting macrophage proliferation and inflammation, with sex-specific effects observed.

Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3

This study shows that proteasome subunit PSMB4 is critical for brown adipocyte differentiation and function, with its loss causing inflammation and adipogenesis disruption via ATF3 activation.

NFE2L1-mediated proteasome function protects from ferroptosis

This study identifies NFE2L1 as a regulator of proteasome function that protects cells from ferroptosis, with implications for cancer and neurodegenerative diseases.

An unexpected lack of difference in superoxide/H2O2 production rates in isolated heart and skeletal muscle mitochondria from a mouse model of Barth Syndrome

The study measures superoxide/H2O2 production in mitochondria from BTHS mice and finds no overall increase, except for a specific site in skeletal muscle.