Cancer BiologybioRxiv
Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner
R. Madsen, R. Knox, W. Pearce…·R. Semple
This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.
DOI 10.1073/pnas.1821093116