Author

R. Semple

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Onishi· 1 shared B. Mahler-Araujo· 1 shared B. Vanhaesebroeck· 1 shared E. J. McKay· 1 shared E. Rasijeff· 1 shared G. V. Brierley· 1 shared H. Webber· 1 shared I. Luijten· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperPhysiology

A. Onishi

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The metabolically protective energy expenditure increase of Pik3r1-related insulin resistance is not explained by Ucp1-mediated thermogenesis

I. Luijten, A. Onishi, E. J. McKay, T. Bengtsson, R. Semple

This study investigates whether increased energy expenditure in Pik3r1-related insulin resistance is due to Ucp1-mediated thermogenesis, finding no evidence for this mechanism.

bioRxiv · Feb 12, 2024Physiology

Anti-Insulin receptor antibodies improve hyperglycaemia in a mouse model of human insulin receptoropathy

G. V. Brierley, H. Webber, E. Rasijeff, S. Grocott, K. Siddle, R. Semple

Anti-insulin receptor antibodies improve glucose tolerance and reduce hyperinsulinemia in a mouse model of insulin receptoropathy but also downregulate receptor expression.

bioRxiv · Mar 20, 2020Biochemistry

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

R. Madsen, R. Knox, W. Pearce, S. Lopez, B. Mahler-Araujo, N. McGranahan, B. Vanhaesebroeck, R. Semple

This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.

bioRxiv · Dec 13, 2018Cancer Biology