S. Lopez

Flagellar Motility is Mutagenic

This study shows that flagellar motility in E. coli increases mutation rates, suggesting it influences bacterial evolution rates.

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune response

This paper identifies three neutralizing monoclonal antibodies against HAstV-VA1 and maps their epitopes, revealing four antigenic sites and immune pressure-driven mutations in a patient with encephalitis.

Nucleolin-RNA interaction modulates rotavirus replication

This study shows nucleolin inhibits rotavirus replication by interacting with viral RNA through G-quadruplex structures, increasing viral production when this interaction is disrupted.

Post-translational modification of SPATULA by SECRET AGENT and SPINDLY promotes organ symmetry transition at the gynoecium apex

The paper shows that SPINDLY and SECRET AGENT modify SPATULA with O-fucose and O-GlcNAc to promote a symmetry transition in the gynoecium.

Regional epidemic dynamics and Delta variant diversity resulted in varying rates of spread of Omicron-BA.1 in Mexico

This paper analyzes the spread dynamics of the Omicron-BA.1 variant in Mexico, finding that regional differences in Delta variant diversity and inter-wave case numbers influenced BA.1 spread rates.

Comparing the evolutionary dynamics of predominant SARS-CoV-2 virus lineages co-circulating in Mexico

The paper analyzes the evolutionary dynamics of five dominant SARS-CoV-2 lineages in Mexico, showing lineage replacement patterns and regional spread.

Mature rotavirus particles contain equivalent amounts of 7meGpppGcap and noncapped viral positive-sense RNAs

The paper quantifies the ratio of capped and noncapped viral RNAs in rotavirus particles and infected cells, finding a 1:1 ratio in mature particles despite dynamic changes during infection.

The capsid precursor protein of astrovirus VA1 is proteolytically processed intracellularly

This study shows that the astrovirus VA1 capsid precursor protein is proteolytically processed intracellularly to form mature infectious particles, independent of trypsin and caspases.

The association of human astrovirus with extracellular vesicles facilitates cell infection and protects the virus from neutralizing antibodies

This study shows that human astrovirus Yuc8 associates with extracellular vesicles, enhancing infection and protecting against neutralizing antibodies.

The gut virome of healthy children during the first year of life is diverse and dynamic

This study characterizes the gut virome of healthy infants during their first year, revealing high diversity and dynamic changes in bacteriophages and eukaryotic viruses.

Saliva sampling is an excellent option to increase the number of SARS CoV2 diagnostic tests in settings with supply shortages

This study demonstrates that saliva sampling can be used for efficient and cost-effective SARS-CoV-2 RNA detection, reducing reliance on scarce reagents and minimizing healthcare worker exposure.

Efficient whole genome sequencing of influenza A viruses

This paper presents a method for efficient whole genome sequencing of influenza A viruses using a single PCR reaction and Illumina sequencing, achieving high coverage for key viral segments.

The guanine nucleotide exchange factor GBF1 participates in rotavirus replication

This study shows that GBF1 is required for rotavirus replication by facilitating VP7 and NSP4 processing and virion assembly.

Oncogenic PIK3CA promotes cellular stemness in an allele dose-dependent manner

This study shows that homozygous PIK3CAH1047R mutations in iPSCs lead to cancer-like changes, while heterozygous mutations do not, highlighting allele dose-dependent effects.

Nanoscale organization of rotavirus replication machineries

This study uses super-resolution microscopy to reveal the nanoscale organization of rotavirus replication machineries, showing seven viral proteins and dsRNA arranged in six concentric layers within viro-plasms.