Functional regulation of an intrinsically disordered protein via a conformationally excited state
K. Madhurima, B. Nandi, S. Munshi, A. Naganathan, A. Sekhar
The paper identifies a thermally accessible folded excited state in the intrinsically disordered bacterial transcription factor CytR, showing it binds DNA via a folding-before-binding conformational selection mechanism.
bioRxiv · Jun 24, 2022Biophysics