R. Pandey

Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection

This study shows Leishmania major manipulates host copper homeostasis to evade immune responses, while macrophages use copper to kill parasites.

Haplo-pheno association for OsNRT1.1 paralog in rice reveals superior haplogroup with high nitrate uptake efficiency

The paper identifies superior and inferior haplotypes of OsNRT1.1 paralogs in rice associated with nitrate uptake efficiency through haplo-pheno association analysis.

Melanocytes Exhibit Distinct Cell States Governed by A Gene Regulatory Network Under Stochastic Influence

The paper identifies distinct melanocyte states and shows stochastic gene expression and epigenetic modification enable their co-existence and response to environmental cues.

Mutations in S2 subunit of SARS-CoV-2 Omicron spike strongly influence its conformation, fusogenicity and neutralization sensitivity

This study investigates how mutations in the S2 subunit of SARS-CoV-2 Omicron spike affect its structure, fusogenicity, and neutralization sensitivity.

Copper-independent lysosomal localization of the Wilson disease protein ATP7B

This study reveals that ATP7B, the Wilson disease protein, has a copper-independent lysosomal localization in hepatocytes and recycles between TGN and TGN-proximal lysosomes for copper transport.

Characterization of Plasmodium falciparum RAP domain proteins-RAP291 and RAP070, and their association with ribosomal RNAs

This study characterizes two Plasmodium falciparum RAP domain proteins, showing they bind ribosomal RNAs and associate with the MSP-1 complex, and inhibit merozoite invasion.

Bronco T (Shirisadi kasaya), a polyherbal formulation ameliorates LPS induced septicemia in rats

Bronco T, a polyherbal formulation, improves survival and lung function in LPS-induced septicemia in rats, with effects comparable to pentoxifylline.

Artemisinin acts by inhibiting Plasmodium falciparum Ddi1, a retropepsin, resulting into the accumulation of ubiquitinated proteins

This study shows that Artemisinin inhibits Plasmodium falciparum Ddi1, leading to ubiquitinated protein accumulation and impaired damage recovery.

SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

Reagent-free Raman and quantitative phase imaging offer a unique morpho-molecular platform for recognition of malignancy and stages of B-cell acute lymphoblastic leukemia

This paper introduces a reagent-free imaging platform combining Raman microscopy and quantitative phase imaging to distinguish stages of B-cell acute lymphoblastic leukemia.

Protein Phosphatase 1 regulates atypical mitotic and meiotic division in Plasmodium sexual stages

The paper investigates the role of Protein Phosphatase 1 (PP1) in atypical mitotic and meiotic divisions during Plasmodium sexual stages, suggesting PP1 inhibitors could block parasite transmission.

Immunogenicity and protective efficacy of a highly thermotolerant, trimeric SARS-CoV-2 receptor binding domain derivative

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

Coarse Raman and optical diffraction tomographic imaging enable label-free phenotyping of isogenic breast cancer cells of varying metastatic potential

This study uses label-free imaging techniques to differentiate metastatic potential in breast cancer cells at single-cell resolution.

MRE11 is crucial for malaria transmission and its absence affects expression of interconnected networks of key genes essential for life

This study shows that MRE11 is essential for Plasmodium development in mosquitoes, with its absence causing transcriptional changes in critical biological processes and blocking parasite transmission.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

This study identifies DEH as an ER-localized protein essential for oocyst mitotic division in Plasmodium berghei, disrupting sporogony and parasite transmission.

A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of Plasmodium berghei during gametogony and parasite transmission.

This study identifies CRK5 as a critical regulator of atypical DNA replication in Plasmodium berghei during gametogony and mosquito transmission.

Real-time dynamics of Plasmodium NDC80 reveals unusual modes of chromosome segregation during parasite proliferation

The paper studies the dynamics of the NDC80 complex in Plasmodium berghei to reveal unique chromosome segregation mechanisms during parasite proliferation.

Origin of a novel CYP20A1 transcript isoform through multiple Alu exaptations creates a potential miRNA sponge

The paper identifies a novel CYP20A1 transcript isoform generated by Alu exaptation that functions as a miRNA sponge in human neurons.

Plasmodium condensin core subunits (SMC2/SMC4) mediate atypical mitosis and are essential for parasite proliferation and transmission

High-resolution transcriptomic profiling of the heart during chronic stress reveals cellular drivers of cardiac fibrosis and hypertrophy

This study uses single-cell transcriptomics to identify cellular drivers of cardiac fibrosis and hypertrophy under chronic stress, revealing sex-specific fibrogenic cell responses.

Differential Strengths Of Molecular Determinants Guide Environment Specific Mutational Fates

The paper uses Deep Mutational Scanning to analyze how environmental factors influence the fitness of single-site mutants in an antibiotic resistance gene, revealing protein stability as a key constraint.