Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney
X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi
This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.
bioRxiv · Jul 1, 2020Pathology