PPIX-binding Proteins Reveal Porphyrin Synthesis and Ferroptosis Link
J. Lynch, Y. Wang, Y. Li, K. Kavidia, Y. Fukuda, S. Ranjit, C. G. Robinson, C. R. Grace, Y. Xia, J. Peng, J. Schuetz
The paper identifies PPIX-binding proteins and shows that increased heme/porphyrin synthesis promotes ferroptosis distinct from canonical ferroptosis, with PRDX3 modulating this process.
bioRxiv · Jun 1, 2022 · PreprintBiochemistry