Author

C. Billon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

T. Burris· 4 shared L. Zhang· 3 shared M. Hayes· 3 shared J. K. Walker· 2 shared M. Losby· 2 shared R. Welch· 2 shared W. Xu· 2 shared A. Chatterjee· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersPharmacology & Toxicology

T. Burris

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4 papers

Recent·Most cited

The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB

M. Losby, M. Hayes, A. Valfort, J. Walker, W. L. Xu, L. Zhang, C. Billon, T. Burris

This study identifies ERRs as regulators of autophagy through TFEB activation in cardiomyocytes, suggesting ERR targeting as a therapeutic strategy for heart failure.

bioRxiv · Mar 2, 2023Cell Biology

A Synthetic ERRα Agonist Induces an Acute AerobicExercise Response and Enhances Exercise Capacity

C. Billon, S. Banerjee, S. Situala, R. Welch, L. Hegazy, B. Elgendy, T. G. Oh, M. Kazantzis, A. Chatterjee, J. Chrivia, M. Hayes, W. Xu, A. Hamilton, J. Huss, L. Zhang, , T. Burris

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

bioRxiv · Oct 5, 2022 · PreprintPharmacology & Toxicology

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function

W. Xu, C. Billon, H. Li, M. Hayes, K. Yu, M. Losby, C. S. Hampton, C. M. Adeyemi, A. Graves, E. Nasiotis, C. Fu, R. Welch, R. M. Evans, L. Pei, J. K. Walker, , L. Zhang

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

bioRxiv · Feb 14, 2022 · PreprintPharmacology & Toxicology

Estrogen-related receptor agonism reverses mitochondrial dysfunction and inflammation in the aging kidney

X. X. Wang, K. Myakala, A. E. Libby, S. Ranjit, S. Takahashi, B. A. Jones, K. Bhasin, Y. Qi, K. Krausz, P. Zerfas, J. Panov, t. J. velenosi, d. P. patel, P. Daneshpajouhnejad, A. Titievsky, , M. Levi

This study shows that ERR agonism improves mitochondrial function and reduces inflammation in aging kidneys, while STING inhibition also reduces inflammation and increases mitochondrial gene expression.

bioRxiv · Jul 1, 2020Pathology